> Back to EJC

2016 editions

  • December 2016
    Joao Incio on mechanisms to explain why obesity promotes cancer.
  • November 2016
    Mike Stratton on how mutational changes in a cancer genome can point to the cause of the cancer.
  • October 2016
    Ruth Muschel on a new target for treatments for colorectal cancer.
  • September 2016
    Freddie Hamdy on the effectiveness of treatments for prostate cancer.
  • August 2016
    Moshe Oren discusses the effects of the microenvironment on cancer cells.
  • July 2016
    Richard Gilbertson on the 'bad luck hypothesis' for the cause of cancer.
  • June 2016
    Key advances in clinical trials.
  • May 2016
    Mark Lemmon on the underlying biochemistry of cancer.
  • April 2016
    Roger Stupp on using alternating electric fields as treatment.
  • March 2016
    Charlotte Vrinten on public perception of deaths from cancer.
  • February 2016
    Guillermo Garcia-Manero on myelodysplastic syndromes (MDS).
  • December 2015/January 2016
    Nazneen Rahman on germline genetic screening in ovarian cancer.

> All 2015 Editions

> All 2014 Editions

> All 2013 Editions

> All 2012 Editions

> All 2011 Editions

EJC News Focus – February 2013

Loading EJC News Focus video

The Hallmarks of Cancer – 12 years on

What does it take to write a paper that will be cited more than 12,000 times? In the case of Douglas Hanahan and Robert Weinberg, it was a day spent discussing the features common to all cancer cells. While the field of cancer cell biology was becoming dauntingly complex, they came up with a straightforward framework for understanding the cancer cell: it had, they said, six underlying essential features. The paper that brought these ideas together, The Hallmarks of Cancer, went on to become a publishing sensation.

More than 10 years on, they updated the paper and introduced another two potential hallmarks, but their basic idea has stood the test of time. Doug Hanahan (Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland) gave the keynote lecture at ESMO 2012; Helen Saul caught up with him there.