- July/August 2015
Thomas Helleday on an exciting new class of drug, MTH1 inhibitors.
- June 2015
Lesley Seymour and Jan Bogaerts on the future of RECIST.
- May 2015
Paul Workman on strategies for overcoming resistance to new drugs.
- April 2015
Highlights from the TAT Congress in Paris.
- March 2015
Christopher Wild on the exposome, a measure of environmental exposure.
- February 2015
Mathematicians are developing a blood flow model for metastasis.
- January 2015
René Bernards on discovering effective drug combinations.
- December 2014
Research on the high rate of burnout among young oncologists.
- November 2014
Carl June on the efficacy of CAR-T cells in treating leukaemia.
- October 2014
News from ESMO 2014 with Solange Peters and Alexander Eggermont.
- September 2014
Discussing how healthcare systems can meet the needs of cancer survivors.
EJC News Focus – December 2013
Precision diagnostics: great potential but is Europe falling behind?
Molecular diagnostics are becoming increasingly important as oncology moves from an era of stratification to personalisation; precision medicine will develop hand in hand with new diagnostic techniques. But according to ESMO President Martine Piccart, there is 'a high unmet need' for molecular diagnostics in Europe. Pharmaceutical companies have little incentive to invest in their development, she says, mainly because of the lack of a clear regulatory path, but also because of the reluctance among oncologists to use available tests.
The groundbreaking SHIVA trial is an excellent example of the central role of the new diagnostics: patients' treatment is determined only by the molecular profile of their tumour, without reference to its anatomical location. Christophe Le Tourneau (Institut Curie, Paris) presented early data at the European Cancer Conference (Amsterdam, Sept 27 – Oct 1, 2013), which hints at the promise of this approach.
In this month's EJC News Focus, Martine Piccart outlines to Helen Saul the cultural and practical changes that will be necessary to drive the development of diagnostics in Europe, and Christophe Le Tourneau demonstrates how these new precision diagnostics could drive progress in oncology.