- December 2016
Joao Incio on mechanisms to explain why obesity promotes cancer.
- November 2016
Mike Stratton on how mutational changes in a cancer genome can point to the cause of the cancer.
- October 2016
Ruth Muschel on a new target for treatments for colorectal cancer.
- September 2016
Freddie Hamdy on the effectiveness of treatments for prostate cancer.
- August 2016
Moshe Oren discusses the effects of the microenvironment on cancer cells.
- July 2016
Richard Gilbertson on the 'bad luck hypothesis' for the cause of cancer.
- June 2016
Key advances in clinical trials.
- May 2016
Mark Lemmon on the underlying biochemistry of cancer.
- April 2016
Roger Stupp on using alternating electric fields as treatment.
- March 2016
Charlotte Vrinten on public perception of deaths from cancer.
- February 2016
Guillermo Garcia-Manero on myelodysplastic syndromes (MDS).
- December 2015/January 2016
Nazneen Rahman on germline genetic screening in ovarian cancer.
EJC News Focus – December 2013
Precision diagnostics: great potential but is Europe falling behind?
Molecular diagnostics are becoming increasingly important as oncology moves from an era of stratification to personalisation; precision medicine will develop hand in hand with new diagnostic techniques. But according to ESMO President Martine Piccart, there is 'a high unmet need' for molecular diagnostics in Europe. Pharmaceutical companies have little incentive to invest in their development, she says, mainly because of the lack of a clear regulatory path, but also because of the reluctance among oncologists to use available tests.
The groundbreaking SHIVA trial is an excellent example of the central role of the new diagnostics: patients' treatment is determined only by the molecular profile of their tumour, without reference to its anatomical location. Christophe Le Tourneau (Institut Curie, Paris) presented early data at the European Cancer Conference (Amsterdam, Sept 27 – Oct 1, 2013), which hints at the promise of this approach.
In this month's EJC News Focus, Martine Piccart outlines to Helen Saul the cultural and practical changes that will be necessary to drive the development of diagnostics in Europe, and Christophe Le Tourneau demonstrates how these new precision diagnostics could drive progress in oncology.