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2016 editions

  • December 2016
    Joao Incio on mechanisms to explain why obesity promotes cancer.
  • November 2016
    Mike Stratton on how mutational changes in a cancer genome can point to the cause of the cancer.
  • October 2016
    Ruth Muschel on a new target for treatments for colorectal cancer.
  • September 2016
    Freddie Hamdy on the effectiveness of treatments for prostate cancer.
  • August 2016
    Moshe Oren discusses the effects of the microenvironment on cancer cells.
  • July 2016
    Richard Gilbertson on the 'bad luck hypothesis' for the cause of cancer.
  • June 2016
    Key advances in clinical trials.
  • May 2016
    Mark Lemmon on the underlying biochemistry of cancer.
  • April 2016
    Roger Stupp on using alternating electric fields as treatment.
  • March 2016
    Charlotte Vrinten on public perception of deaths from cancer.
  • February 2016
    Guillermo Garcia-Manero on myelodysplastic syndromes (MDS).
  • December 2015/January 2016
    Nazneen Rahman on germline genetic screening in ovarian cancer.

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EJC News Focus – November 2016

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Mutational signatures reveal the causes of cancers

The mutational signature of an individual cancer genome tells the story of its own development, its cause and even how it could have been prevented, according to Mike Stratton, Director of the Sanger Institute (Cambridge, UK). His team has described approximately 40 signatures which they believe will eventually point to the causes of the vast majority of cancers.

The latest results show that the signature caused by tobacco is present in lung cancers but - intriguingly - not in other smoking-related cancers such as bladder cancer. In this EJC News Focus, he explains to Helen Saul the implications of this finding and how geneticists are teaming up with epidemiologists to suggest new approaches in the prevention of cancer.

Reference: Mutational signatures associated with tobacco smoking in human cancer. Stratton M et al, Science 2016. This work was presented at EACR24 (Manchester, UK; June 2016)