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2016 editions

  • December 2016
    Joao Incio on mechanisms to explain why obesity promotes cancer.
  • November 2016
    Mike Stratton on how mutational changes in a cancer genome can point to the cause of the cancer.
  • October 2016
    Ruth Muschel on a new target for treatments for colorectal cancer.
  • September 2016
    Freddie Hamdy on the effectiveness of treatments for prostate cancer.
  • August 2016
    Moshe Oren discusses the effects of the microenvironment on cancer cells.
  • July 2016
    Richard Gilbertson on the 'bad luck hypothesis' for the cause of cancer.
  • June 2016
    Key advances in clinical trials.
  • May 2016
    Mark Lemmon on the underlying biochemistry of cancer.
  • April 2016
    Roger Stupp on using alternating electric fields as treatment.
  • March 2016
    Charlotte Vrinten on public perception of deaths from cancer.
  • February 2016
    Guillermo Garcia-Manero on myelodysplastic syndromes (MDS).
  • December 2015/January 2016
    Nazneen Rahman on germline genetic screening in ovarian cancer.

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EJC News Focus – December 2016

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Why does obesity promote cancer?

Scientists have come up with various mechanisms to explain why obesity promotes cancer. A group in Portugal believes that inflammation may be key. Joao Incio and his colleagues at Harvard Medical School, Boston, USA say that inflammation may exert its effect by accelerating immune cell recruitment to tumours and boosting collagen-producing cells.

The resulting increase in fibrosis – desmoplasia – may in turn prevent chemotherapy from reaching its intended target. As Joao Incio tells Helen Saul in this month's EJC News Focus, the research has interesting implications, from the need to think about testing treatments on overweight mice, to the possibility of a new role in cancer treatment for some old and cheap drugs.

The research was presented at EACR24 in Manchester, UK; June 2016. Joao Incio is now at I3S Institute for Innovation and Health Research, Oporto, Portugal